반응 #1702063

반응 방정식

AlCl3

aluminum chloride

phenol

dichloromethane

aluminum chloride

2,5-dichloro-2,5-dimethylhexane

→

5,6,7,8-tetrahydro-2-hydroxy-5,5,8,8-tetramethyl naphthalene

용매

water

반응 조건

후처리

1. 1
   추출extracted by ethyl acetate
2. 2
   세척The organic layer was washed by water
3. 3
   건조a saturated sodium hydrogen carbonate aq. solution, and a saturated saline solution, dried over magnesium sulfate
4. 4
   농축concentrated under reduced pressure
5. 5
   기타The crude product was purified by recrystallization in a solvent of hexane

실험 절차

The synthesis process is as set forth in the chemical reaction formula below. The AlCl3 in the reaction path stands for aluminum chloride. Into phenol (1.02 g, 10.8 mmol) were added anhydrous dichloromethane (5 mL), aluminum chloride (144 mg, 1.08 mmol), and 2,5-dichloro-2,5-dimethylhexane (2.18 g, 11.9 mmol) followed by stirring at room temperature for 19 hours. The reaction solution was poured into cold water and extracted by ethyl acetate. The organic layer was washed by water, a saturated sodium hydrogen carbonate aq. solution, and a saturated saline solution, dried over magnesium sulfate, and concentrated under reduced pressure. The crude product was purified by recrystallization in a solvent of hexane. The yield was 1.83 g (83%).

출처