반응 #170165

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3-(2-thienyl)propanoic acid

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title compound

3-(2-Thienyl)propanol

용매

THF

반응 조건

후처리

1. 1
   온도After cooling down to 0° C.
2. 2
   기타the reaction was quenched by addition of a saturated solution of potassium carbonate (5 mL)
3. 3
   기타The aqueous layer was separated
4. 4
   추출extracted with ethyl acetate (2×15 mL) and diethyl ether (2×15 mL)
5. 5
   건조The combined organic phases were dried over sodium sulfate
6. 6
   여과filtered
7. 7
   농축concentrated to dryness

실험 절차

Borane methylsulfide complex (6.4 mL, 12.8 mmol) was added to a solution of 3-(2-thienyl)propanoic acid (1.0 g, 6.4 mmol) in THF (18 mL) at 0° C. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature for 3 additional hours. After cooling down to 0° C., the reaction was quenched by addition of a saturated solution of potassium carbonate (5 mL). The aqueous layer was separated and extracted with ethyl acetate (2×15 mL) and diethyl ether (2×15 mL). The combined organic phases were dried over sodium sulfate, filtered and concentrated to dryness. The title compound was obtained as a colorless oil (1.0 g, 100%).

출처