반응 #1701032

반응 방정식

4-chloropyridine

N-methylallylamine

→

4-(N-methylallylamino)pyridine

수율 75.0%

반응 조건

후처리

1. 1
   기타after which the mixture was degassed under vacuum
2. 2
   기타the vessel was sealed
3. 3
   workup.DISSOLUTIONthe contents were dissolved in water
4. 4
   추출The aqueous solution was extracted with several portions of diethyl ether
5. 5
   추출The ether extract
6. 6
   여과was filtered
7. 7
   기타evaporated
8. 8
   workup.DISTILLATIONThe residue was distilled under vacuum

실험 절차

Silane 1a was prepared by first preparing and then hydrosilating 4-(N-methylallylamino)pyridine with diethoxy(methyl)silane, (EtO)2MeSiH. The 4-(N-methylallylamino)pyridine was first obtained by reaction of 4-chloropyridine and N-methylallylamine. Thus, 4-chloropyridine (11.4 g; 0.1 mol) and N-methylallylamine (7.1 g; 0.1 mol) were combined in a glass ampoule or steel container, after which the mixture was degassed under vacuum and the vessel was sealed. The vessel was heated for three days at 130° C. The vessel was thereafter opened and the contents were dissolved in water and then neutralized with 10% aqueous NaOH. The aqueous solution was extracted with several portions of diethyl ether. The ether extract was filtered and evaporated. The residue was distilled under vacuum to give 4-(N-methylallylamino)pyridine (11.1 g; 75%; b.p. 70° C. @0.1 torr). 4-(N-Methylallylamino)pyridine (4.45 g; 0.030 mol), MeSiH(OR)2 (6.7 g; 0.050 mol) and H2PtCl6 (60 μL; 0.080 mol/L in i-PrOH; 4.6×10-6 mol) were combined and heated under vacuum in a sealed vessel for 10 hours at 130° C. Distillation of the products gave Silane 1a, N-(3-(diethoxy(methyl)silyl)propyl)-N-methyl-4-aminopyridine, as a colorless liquid (6.3 g; 74%; b.p. 122-127° C. @0.05 torr). The product was characterized by elemental analysis, infrared, 1H and 13C-NMR spectroscopy, and gas chromatography-mass spectrometry.

출처