반응 #1701

반응 방정식

diethyl 1-(6-chloro-1-oxoindan-2-yl)imidazole-2,4-dicarboxylate

ammonium acetate

acetic acid

→

ethyl 7-chloro-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-2-carboxylate

수율 61.7%

용매

acetonitrile

methanol

acetone

반응 조건

후처리

1. 1
   세척After washing the precipitate with water
2. 2
   기타with methyl ethyl ketone, the solid obtained

실험 절차

The procedure is as in Example 1 but starting from 5 g of diethyl 1-(6-chloro-1-oxoindan-2-yl)imidazole-2,4-dicarboxylate, 118 g of ammonium acetate and 190 ml of acetic acid. After washing the precipitate with water and then with methyl ethyl ketone, the solid obtained is first of all ground in acetonitrile and then in methanol and finally in acetone to obtain 2.7 g of ethyl 7-chloro-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-2-carboxylate in the form of a brown solid melting above 260° C. (analysis % calculated C: 58.28, H: 3.67, Cl: 10.75, N: 12.74; % found C: 58.6, H: 3.4, Cl: 10.4, N: 13.1).

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