반응 #170047

반응 방정식

tert-Butyl 7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

triethylamine

1-Propanesulfonyl chloride

→

product

수율 81.2%

tert-Butyl 1-benzyl-7-(propylsulfonamidomethyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

수율 81.2%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   workup.DISSOLUTIONThe solid immediately dissolved
2. 2
   세척washed with brine (1×50 mL)
3. 3
   기타The organic phase was collected
4. 4
   기타dried on MgSO4
5. 5
   기타the volatiles were evaporated under reduced pressure

실험 절차

tert-Butyl 7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (0.600 g, 1.637 mmol) was suspended in dichloromethane (5 mL) and triethylamine (0.228 mL, 1.637 mmol) and cooled to 0° C. 1-Propanesulfonyl chloride (0.184 mL, 1.64 mmol) was added. The solid immediately dissolved. The mixture was stirred 35 minutes, and then it was diluted with dichloromethane and washed with brine (1×50 mL). The organic phase was collected, dried on MgSO4 and the volatiles were evaporated under reduced pressure, yielding the product as a pale yellow solid (628.3 mg, 1.33 mmol, 81%).

출처