반응 #170046

반응 방정식

tert-Butyl 7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

triethylamine

Ethanesulfonyl chloride

→

solid

수율 87.0%

tert-Butyl 1-benzyl-7-(ethylsulfonamidomethyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

수율 87.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   workup.DISSOLUTIONthe solid gradually dissolved
2. 2
   세척by washing it with brine (1×50 mL)
3. 3
   기타The organic phase was collected
4. 4
   기타dried on MgSO4
5. 5
   기타evaporated
6. 6
   기타The residue was purified by flash-chromatography on silica gel (100% DCM)

실험 절차

tert-Butyl 7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (0.600 g, 1.637 mmol) was suspended in dichloromethane (5 mL) and triethylamine (0.228 mL, 1.637 mmol) and cooled to 0° C. Ethanesulfonyl chloride (0.155 mL, 1.64 mmol) was added and the solid gradually dissolved. After 30 minutes the reaction was stopped by washing it with brine (1×50 mL). The organic phase was collected and dried on MgSO4, evaporated. The residue was purified by flash-chromatography on silica gel (100% DCM). Product was obtained as yellow solid (0.653 g, 1.42 mmol, 87%).

출처