반응 #169919

반응 방정식

4-amino-N-(3-chloro-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide

N,N-diisopropylethylamine

propanoyl chloride

→

desired product

수율 47.0%

4-Amino-N-(3-chloro-4-fluorophenyl)-N′-(propionyloxy)-1,2,5-oxadiazole-3-carboximidamide

수율 47.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated
2. 2
   기타purified by preparative LCMS

실험 절차

A solution of 4-amino-N-(3-chloro-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide (0.1 g, 0.37 mmol) and N,N-diisopropylethylamine (0.16 mL, 0.92 mmol) in dichloromethane (4 mL) was treated with propanoyl chloride (38 μL, 0.44 mmol) and stirred for 1 h. The reaction mixture was concentrated and purified by preparative LCMS to give the desired product (57 mg, 47%). LCMS for C12H12ClFN5O3 (M+H)+: m/z=328.0.

출처