반응 #1699

반응 방정식

ammonium acetate

diethyl 1-(1-oxoindan-2-yl)imidazole-2,4-dicarboxylate

→

ethyl 4,5-dihydro-4-oxo-10H-imidazol[1,2-a]indeno[1,2-e]pyrazine-2-carboxylate

수율 37.7%

용매

acetic acid

반응 조건

후처리

1. 1
   온도the mixture is heated
2. 2
   온도to reflux for 2 hours
3. 3
   온도After cooling to a temperature
4. 4
   기타close to 20° C. the precipitate
5. 5
   기타formed
6. 6
   여과is filtered off
7. 7
   세척rinsed with distilled water

실험 절차

51.2 g of ammonium acetate are added in small portions to a solution of 2 g of diethyl 1-(1-oxoindan-2-yl)imidazole-2,4-dicarboxylate in 80 ml of acetic acid and the mixture is heated to reflux for 2 hours. After cooling to a temperature close to 20° C. the precipitate formed is filtered off and rinsed with distilled water and then with methyl ethyl ketone (2×10 ml) to give 0.65 g of ethyl 4,5-dihydro-4-oxo-10H-imidazol[1,2-a]indeno[1,2-e]pyrazine-2-carboxylate in the form of a beige solid melting above 260° C. (analysis % calculated C: 65.08, H: 4.44, N: 14.23; % found C: 65.2, H: 4.3, N: 13.8).

출처