반응 #169733

반응 방정식

K2CO3

4-methylpyridin-3-amine

hydrogen chloride

hydrogen peroxide

→

2-chloro-4-methylpyridin-3-amine

반응 조건

후처리

1. 1
   추출the mixture was extracted with AcOEt
2. 2
   건조The organic layer was dried over MgSO4
3. 3
   농축concentrated in vacuo

실험 절차

A mixture of 4-methylpyridin-3-amine (0.62 g), 12N hydrogen chloride (3.8 mL) and 30% hydrogen peroxide (0.75 mL) was stirred at 0° C. to room temperature for 1 h. The mixture was neutralized with K2CO3, and the mixture was extracted with AcOEt. The organic layer was dried over MgSO4, and concentrated in vacuo to give 2-chloro-4-methylpyridin-3-amine (0.75 g) as an orange solid.

출처