반응 #169636

반응 방정식

2-chloropyridine-4-methanol

thionyl bromide

→

4-(bromomethyl)-2-chloropyridine

용매

dichloromethane

반응 조건

후처리

1. 1
   기타the reaction was quenched with saturated aqueous ammonium chloride
2. 2
   세척The organic solution was washed 2× with water
3. 3
   건조dried over sodium sulfate
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo

실험 절차

To a solution of 2-chloropyridine-4-methanol (1.02 g, 7.10 mmol) in 15 mL of dichloromethane was added thionyl bromide (1.77 g, 8.53 mmol) dropwise. After 15 min, the reaction was quenched with saturated aqueous ammonium chloride. The organic solution was washed 2× with water, dried over sodium sulfate, filtered, and concentrated in vacuo to provide 4-(bromomethyl)-2-chloropyridine that gave a mass ion (ES+) of 208.0 for [M+H]+.

출처