반응 #169619

반응 방정식

methyl 1-amino-4-bromo-2-naphthoate hydrobromide

sodium hydroxide

→

1-amino-4-bromo-2-naphthoic acid

용매

THF

반응 조건

후처리

1. 1
   온도heated at 90° C. for 2 h
2. 2
   기타The solvent was removed in vacuo and hydrochloric acid (1 N aqueous)
3. 3
   workup.ADDITIONwas added until pH ˜2
4. 4
   여과The beige solid was collected via filtration
5. 5
   세척washed twice with water
6. 6
   기타dried

실험 절차

To a solution of methyl 1-amino-4-bromo-2-naphthoate hydrobromide (2.00 g, 5.54 mmol) in 20 mL of THF was added sodium hydroxide (11.1 mL, 20% aqueous, 55.4 mmol). The mixture was stirred at 50° C. for 20 h, then heated at 90° C. for 2 h. The solvent was removed in vacuo and hydrochloric acid (1 N aqueous) was added until pH ˜2. The beige solid was collected via filtration, washed twice with water, and dried to provide 1-amino-4-bromo-2-naphthoic acid that gave a mass ion (ES+) of 266.0 (79Br) for [M+H]+.

출처