반응 #169520

반응 방정식

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid

SOCl2

→

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonyl chloride

용매

toluene

반응 조건

후처리

1. 1
   workup.DISTILLATIONThe toluene and SOCl2 are distilled from the reaction mixture after 30 minutes
2. 2
   workup.ADDITIONAdditional toluene (2.5 vol) is added
3. 3
   workup.DISTILLATIONdistilled again

실험 절차

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid (1.2 eq) is slurried in toluene (2.5 vol) and the mixture heated to 60° C. SOCl2 (1.4 eq) is added via addition funnel. The toluene and SOCl2 are distilled from the reaction mixture after 30 minutes. Additional toluene (2.5 vol) is added and distilled again.

출처