반응 #169519

반응 방정식

(2,2-difluoro-1,3-benzodioxol-5-yl)-acetonitrile

KOH

MTBE

→

(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonitrile

용매

water

반응 조건

후처리

1. 1
   온도The reaction mixture is cooled
2. 2
   세척The organic phase is washed with water and brine
3. 3
   기타the solvent is removed

실험 절차

A mixture of (2,2-difluoro-1,3-benzodioxol-5-yl)-acetonitrile (1.0 eq), 50 wt % aqueous KOH (5.0 eq) 1-bromo-2-chloroethane (1.5 eq), and Oct4NBr (0.02 eq) is heated at 70° C. for 1 h. The reaction mixture is cooled then worked up with MTBE and water. The organic phase is washed with water and brine then the solvent is removed to afford (2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonitrile.

출처