반응 #169494

반응 방정식

3-hydroxybenzonitrile

Ethyl azidoacetate

sodium ascorbate

→

title compound

Ethyl[4-(3-Hydroxyphenyl)-1H-1,2,3-triazol-1-yl]acetate

용매

tert-butanol

water

반응 조건

후처리

1. 1
   기타The solution was evaporated to dryness in vacuo
2. 2
   workup.DISSOLUTIONthe residue was dissolved in EtOAc (100 mL)
3. 3
   건조dried (MgSO4)
4. 4
   여과filtered
5. 5
   기타evaporated in vacuo

실험 절차

Ethyl azidoacetate (14.9 g, 115 mmol) was dissolved in tert-butanol (200 mL), and 95% 3-hydroxybenzonitrile (13.7 g, 110 mmol) was added. A solution of sodium ascorbate (2.18 g, 11 mmol) in water (100 mL) was added, followed by a 0.3 M solution of copper sulfate under argon. The mixture was stirred at room temperature for 12 hours. The solution was evaporated to dryness in vacuo, the residue was dissolved in EtOAc (100 mL), dried (MgSO4), filtered, evaporated in vacuo to give the title compound as brown crystals in ˜100% (27.7 g) yield.

출처