반응 #169470

반응 방정식

(4-nitro-phenyl)-acetic acid ethyl ester

→

title compound

수율 96.0%

(4-Amino-phenyl)-acetic acid ethyl ester

수율 96.0%

용매

methanol

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through celite
2. 2
   세척washed with methanol (2×20 mL)
3. 3
   기타the filtrate was evaporated in vacuo

실험 절차

A solution of (4-nitro-phenyl)-acetic acid ethyl ester (Preparation 266, 3.4 g, 16.1 mmol) in methanol (100 mL) was degassed with argon for 15 min, treated with 10% palladium on charcoal (700 mg), and then stirred at room temperature under hydrogen (balloon pressure) for 16 hours. The reaction mixture was filtered through celite, washed with methanol (2×20 mL) and the filtrate was evaporated in vacuo to afford the title compound as an oil in 96% yield, 2.8 g.

출처