반응 #169469

반응 방정식

NaOH

(4-nitro-phenyl)-acetic acid

sulphuric acid

ethanol

→

title compound

수율 98.0%

(4-Nitro-phenyl)-acetic acid ethyl ester

수율 98.0%

반응 조건

후처리

1. 1
   온도the reaction mixture was heated
2. 2
   온도to reflux for 16 hours
3. 3
   추출extracted with EtOAc (3×50 mL)
4. 4
   건조The combined organic layers were dried (Na2SO4)
5. 5
   기타evaporated in vacuo

실험 절차

To a stirred solution of (4-nitro-phenyl)-acetic acid (3 g, 16.4 mmol) in ethanol (30 mL) was added sulphuric acid (1 mL) and the reaction mixture was heated to reflux for 16 hours. The reaction mixture was neutralized with 2N aq. NaOH solution and extracted with EtOAc (3×50 mL). The combined organic layers were dried (Na2SO4) and evaporated in vacuo to afford the title compound as a light yellow oil in 98% yield, 3.4 g.

출처