반응 #169391

반응 방정식

Ethyl 4-chloroacetoacetate

cyclopropanecarboxamide

→

title compound

수율 50.0%

Ethyl (2-cyclopropyl-1,3-oxazol-4-yl)acetate

수율 50.0%

용매

toluene

1,4-dioxane

반응 조건

후처리

1. 1
   기타then evaporated in vacuo
2. 2
   기타The crude solid was purified by column chromatography on silica gel (80:20 petroleum ether: EtOAc)

실험 절차

Ethyl 4-chloroacetoacetate (20.0 g, 122.0 mmol) was added to cyclopropanecarboxamide (3.52 g, 41.5 mmol) in toluene (100 mL) and 1,4-dioxane (100 mL). The mixture was refluxed at 120° C. for 17 hours then evaporated in vacuo. The crude solid was purified by column chromatography on silica gel (80:20 petroleum ether: EtOAc) to afford the title compound as a white solid in 50% yield, 4.00 g.

출처