반응 #169339

반응 방정식

Methyl 2-bromo-2-methylpropanoate

2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

potassium iodide

cesium carbonate

→

title compound

수율 92.0%

Methyl 2-(2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-methylpropanoate

수율 92.0%

용매

water

DMF

반응 조건

후처리

1. 1
   여과The mixture was filtered
2. 2
   세척the solid was washed with water (500 mL)

실험 절차

Methyl 2-bromo-2-methylpropanoate (663 mL, 5.13 mmol) was added to 2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (358.1 g, 1.28 mol) (see Preparation 40), potassium iodide (21.3 g, 128 mmol) and cesium carbonate (1670 g, 5.13 mol) in DMF (7162 mL). The mixture was heated at 60° C. for 19 hours. The reaction mixture was diluted with water (7000 mL) and stirred at room temperature for 42 hours. The mixture was filtered and the solid was washed with water (500 mL) to afford the title compound as a beige solid in 92% yield, 445.8 g.

출처