반응 #1693140

반응 방정식

4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine

ethylene chlorohydrin

sodium carbonate

sodium iodide

→

1-(2-hydroxyethyl)-4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine

용매

ethanol

반응 조건

후처리

1. 1
   여과filtered hot
2. 2
   기타the filtrate is evaporated to dryness
3. 3
   기타The residual oil is purified by column chromatography on silica gel with acetic acid ethyl ester-ethanol (1:1)
4. 4
   세척as eluting agent

실험 절차

1.77 g of 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine, 0.8 g. of ethylene chlorohydrin, 1.2 g. of sodium carbonate and a few crystals of sodium iodide are heated under reflux conditions in 10 ml. of ethanol for 24 hours and filtered hot and the filtrate is evaporated to dryness. The residual oil is purified by column chromatography on silica gel with acetic acid ethyl ester-ethanol (1:1) as eluting agent. The 1-(2-hydroxyethyl)-4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine obtained from the eluate melts at 96°-98°C. after recrystallization from cyclohexane.

출처