반응 #1693137

반응 방정식

4'-[(2-chloroethyl)thio]acetanilide

4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine

potassium carbonate

potassium iodide

→

4'-{[2-[4-(p-fluorophenyl)-3,6-dihydro-1(2H)-pyridyl]-ethyl]thio}acetanilide

용매

ethanol

water

반응 조건

후처리

1. 1
   기타The solvent is evaporated under reduced pressure
2. 2
   세척washed with water

실험 절차

1.8 G. of 4'-[(2-chloroethyl)thio]acetanilide, 2.7 g. of 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine, 4.5 g. of potassium carbonate and a few crystals of potassium iodide are heated under reflux conditions in 50 ml. of ethanol and 5 ml. of water for 16 hours. The solvent is evaporated under reduced pressure, the residue is taken up in chloroform and washed with water. From the organic phase there is obtained crude 4'-{[2-[4-(p-fluorophenyl)-3,6-dihydro-1(2H)-pyridyl]-ethyl]thio}acetanilide which melts at 150°-152°C. after recrystallization from acetic acid ethyl ester.

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