반응 #169283

반응 방정식

1-chloro-4-isocyanatobenzene

(5-aminopyridin-3-yl)(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

→

title compound

수율 49.0%

1-(4-chlorophenyl)-3-{5-[(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}urea

수율 49.0%

용매

pyridine

반응 조건

후처리

1. 1
   기타then evaporated in vacuo
2. 2
   기타to yield the product as a crude residue
3. 3
   기타The crude residue was purified by preparative HPLC

실험 절차

1-chloro-4-isocyanatobenzene (24 mg, 0.15 mmol) was added to (5-aminopyridin-3-yl)(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (30 mg, 0.12 mmol) (Preparation 232) in pyridine (1.0 mL). The mixture was stirred at room temperature overnight then evaporated in vacuo to yield the product as a crude residue. The crude residue was purified by preparative HPLC to afford the title compound in 49% yield, 24 mg.

출처