반응 #169225

반응 방정식

diethyl ether

4-[6-(4-Hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

HCl

→

title compound

수율 93.2%

(6-(4-Hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1H-pyrazolo[3,4-b]pyridin-4-yl)-piperazin-1-yl-methanone

수율 93.2%

용매

methanol

dioxane

반응 조건

후처리

1. 1
   기타the resulting precipitated
2. 2
   여과was filtered
3. 3
   세척washed once with diethyl ether

실험 절차

To a solution of 4-[4-[6-(4-Hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester (0.25 g, 0.35 mmol) in methanol (5 ml) was added 4N HCl in dioxane (0.9 ml). The reaction mixture was stirred at room temperature for 18 hours, diethyl ether was then added, the resulting precipitated was filtered and washed once with diethyl ether to afford the hydrochloride salt of the title compound (0.175 g, 82%) as an orange solid.

출처