반응 #169220

반응 방정식

4-iodo-benzoyl chloride

piperidine

→

title compound

수율 100.1%

(4-iodo-phenyl)-piperidin-1-yl-methanone

수율 100.1%

용매

dichloromethane

반응 조건

후처리

1. 1
   온도The reaction mixture was heated
2. 2
   온도at reflux for 1.5 hour
3. 3
   세척The organic layer was washed with an aqueous 1M HCl solution, brine
4. 4
   건조dried (Na2SO4)
5. 5
   여과filtered
6. 6
   농축concentrated under vacuum

실험 절차

To a suspension of 4-iodo-benzoyl chloride (2.00 g, 7.51 mmol) in dichloromethane (25 mL) was added piperidine (1.85 mL, 18.76 mmol). The reaction mixture was heated at reflux for 1.5 hour and then cooled to room temperature. The organic layer was washed with an aqueous 1M HCl solution, brine, dried (Na2SO4), filtered, concentrated under vacuum to give the title compound (2.37 g, 100%) as a white solid.

출처