반응 #169202

반응 방정식

3-aminopyrazole

diethyl oxalacetate sodium salt

acetic acid

→

title compound

수율 28.4%

6-Hydroxy-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid ethyl ester

수율 28.4%

용매

water

water

반응 조건

후처리

1. 1
   온도then cooled to room temperature
2. 2
   여과filtered
3. 3
   세척The precipitate was washed with water
4. 4
   기타dried

실험 절차

To a solution of 3-aminopyrazole (224 g, 2.7 mol) in water (1 L) were added a solution of diethyl oxalacetate sodium salt (567 g, 2.7 mol) in water (1.3 L) and then acetic acid in 4 portions (0.8 L). The reaction mixture was heated at 85° C. for 15 hours then cooled to room temperature and filtered. The precipitate was washed with water and then dried to afford the title compound as an orange solid (159 g, 28%). 1H NMR (250 MHz, DMSO): δ 1.35 (t, 3H), 4.36 (q, 2H), 6.69 (s, 1H), 8.16 (s, 1H).

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