반응 #169095
ord-3ff3a25f083043bba883e7f082e9c364
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과the reaction mixture was filtered through a pad of CELITE
- 2여과filter agent
- 3세척The pad was rinsed with acetonitrile
- 4농축the combined filtrates were concentrated under reduced pressure
실험 절차
7-Bromo-3-nitro-N-(tetrahydro-2H-pyran-4-ylmethyl)quinolin-4-amine (20 g, 55 mmol) was dissolved in a mixture of acetonitrile (500 mL) and isopropyl alcohol (50 mL) and the solution was placed in a pressure bottle. Platinum on carbon (5%, 2 g) was then added and the reaction mixture was shaken under H2 at 48 PSI (3.3×105 Pa). After 2 hours, the reaction mixture was filtered through a pad of CELITE filter agent. The pad was rinsed with acetonitrile and the combined filtrates were concentrated under reduced pressure to give 7-bromo-N-(tetrahydro-2H-pyran-4-ylmethyl)quinoline-3,4-diamine which was carried forward without further purification assuming quantitative yield.