반응 #169072

반응 방정식

tert-butyl N-{2-[(3-nitro[1,5]naphthyridin-4-yl)amino]-1,1-dimethylethyl}carbamate

hydrogen

→

tert-butyl N-{2-[(3-amino[1,5]naphthyridin-4-yl)amino]-1,1-dimethylethyl]carbamate

수율 95.7%

용매

acetonitrile

Pt/C

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through a layer of CELITE
2. 2
   여과filter aid
3. 3
   세척the filter cake was rinsed with acetonitrile
4. 4
   농축The filtrate was concentrated under reduced pressure

실험 절차

A Parr vessel was charged with a solution of tert-butyl N-{2-[(3-nitro[1,5]naphthyridin-4-yl)amino]-1,1-dimethylethyl}carbamate (12.62 g, 34.9 mmol) in acetonitrile (100 mL) and 5% Pt/C (2.00 g). The vessel was placed under hydrogen pressure (50 psi, 3.4×105 Pa) until hydrogen uptake ceased. The reaction mixture was filtered through a layer of CELITE filter aid and the filter cake was rinsed with acetonitrile. The filtrate was concentrated under reduced pressure to provide 11.07 g of tert-butyl N-{2-[(3-amino[1,5]naphthyridin-4-yl)amino]-1,1-dimethylethyl]carbamate as a bright yellow foam.

출처