반응 #1690032

반응 방정식

4,5-Methylenedioxysalicylic acid

carbonyldiimidazole

2-amino-1-propanol

→

2-(2-hydroxy-4,5-methylenedioxybenzamido)-1-propanol

수율 52.0%

용매

methylene chloride

반응 조건

후처리

1. 1
   기타An acidic quench
2. 2
   기타subsequent purification by flash chromatography (SiO2)

실험 절차

4,5-Methylenedioxysalicylic acid was activated by carbonyldiimidazole in methylene chloride and combined with 2-amino-1-propanol in essentially an identical manner as for Example 1 above. An acidic quench and subsequent purification by flash chromatography (SiO2) using (1:1) hexane-ethyl acetate gave 2-(2-hydroxy-4,5-methylenedioxybenzamido)-1-propanol as a waxy white solid in 52% yield.

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