반응 #168878

반응 방정식

(3-chloro-4-methoxy-5-methylpyridin-2-yl)methanol

thionyl chloride

→

title compound

3-Chloro-2-(chloromethyl)-4-methoxy-5-methylpyridine hydrochloride

용매

chloroform

반응 조건

후처리

1. 1
   온도under cooling on ice
2. 2
   농축Thereafter, the reaction solution was concentrated
3. 3
   세척it was then washed with a mixed solvent of ether-hexane

실험 절차

The above (3-chloro-4-methoxy-5-methylpyridin-2-yl)methanol (530 mg) was dissolved in 20 ml of chloroform, and thionyl chloride (1.03 ml) was then added dropwise to the solution under cooling on ice. The resulting mixture was stirred at room temperature for 3 hours. Thereafter, the reaction solution was concentrated, and it was then washed with a mixed solvent of ether-hexane, so as to obtain the title compound (410 mg) as a solid.

출처