반응 #1687625

반응 방정식

65

3-Mercapto-5(3-pyridyl)-1,2,4-triazole

potassium hydroxide

methyl iodide

→

3-Methylthio-5-(3-pyridyl)-1,2,4-triazole

용매

water

ether

반응 조건

후처리

1. 1
   기타The ether phase was separated
2. 2
   추출the aqueous phase extracted with 3×100 ml of ether
3. 3
   건조The combined organic phases were dried over magnesium sulphate
4. 4
   기타Removal of the solvent in vacuo
5. 5
   기타gave a colorless solid, 66

실험 절차

A solution of 20 g (0.100 mol) of 65 and 7.5 g (0.150 mol) of potassium hydroxide in 100 ml of water was mixed with a solution of 10 ml (0.160 mol) of methyl iodide in 100 ml of ether. After addition of 1 g of tetrabutylammonium hydrogen sulphate the mixture was stirred overnight at room temperature. The ether phase was separated and the aqueous phase extracted with 3×100 ml of ether. The combined organic phases were dried over magnesium sulphate. Removal of the solvent in vacuo gave a colorless solid, 66. Yield: 17.0 g (0.089 mol, 89%).

출처