반응 #1686211

반응 방정식

4,6-dichloro-5-(4-methylphenyl)pyrimidine

tetrahydrofuran

ethylene glycol

sodium hydride

→

2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol

용매

acetic acid

반응 조건

후처리

1. 1
   온도cooling
2. 2
   온도cooling for 30 minutes
3. 3
   workup.STIRRINGstirred at room temperature for two hours
4. 4
   농축concentrated under reduced pressure
5. 5
   workup.DISSOLUTIONThe residue is dissolved in ethyl acetate
6. 6
   세척washed
7. 7
   기타dried
8. 8
   농축concentrated to dryness under reduced pressure
9. 9
   기타The residue is crystallized from hexane

실험 절차

To a mixture of tetrahydrofuran (400 ml) and ethylene glycol (60 ml) is added with stirring sodium hydride (60% dispersion, 3.38 g) under ice-cooling, and thereto is added 4,6-dichloro-5-(4-methylphenyl)pyrimidine (20.0 g). The mixture is stirred under ice-cooling for 30 minutes, and then stirred at room temperature for two hours. The mixture is weakly acidified with acetic acid, and concentrated under reduced pressure. The residue is dissolved in ethyl acetate, and washed, dried, and concentrated to dryness under reduced pressure. The residue is crystallized from hexane to give 2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (21.85 g).

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