반응 #1686166

반응 방정식

methyl 6-methoxy-1,3-benzodioxole-5-carboxylate

sodium hydroxide

ethanol

→

6-methoxy-1,3-benzodioxole-5-carboxylic acid

수율 85.7%

용매

water

반응 조건

후처리

1. 1
   온도was heated 1 hour
2. 2
   온도at reflux
3. 3
   세척washed with diethyl ether (2×)
4. 4
   workup.ADDITIONtreated with concentrated hydrochloric acid
5. 5
   온도cooled in an ice-bath
6. 6
   기타The solids were collected
7. 7
   세척washed with water (2×)
8. 8
   기타dried under vacuum at 70° C.

실험 절차

A mixture of methyl 6-methoxy-1,3-benzodioxole-5-carboxylate (3 g, 14 mmol), prepared as in Example 1, 20% sodium hydroxide (50 mL) and ethanol (25 mL) was heated 1 hour at reflux and then diluted with water, washed with diethyl ether (2×), treated with concentrated hydrochloric acid and cooled in an ice-bath. The solids were collected, washed with water (2×) and dried under vacuum at 70° C. to give 6-methoxy-1,3-benzodioxole-5-carboxylic acid (2.3 g, 12 mmol), m.p. 151° C.

출처