반응 #1686162

반응 방정식

methyl 6-hydroxy-1,3-benzodioxole-5-carboxylate

sodium hydride

iodomethane

→

methyl 6-methoxy-1,3-benzodioxole-5-carboxylate

수율 107.7%

용매

DMF

반응 조건

후처리

1. 1
   추출the mixture was extracted with diethyl ether (2×)
2. 2
   세척The combined extracts were washed with water (3×) and brine (1×)
3. 3
   농축concentrated

실험 절차

A mixture of methyl 6-hydroxy-1,3-benzodioxole-5-carboxylate (2.7 g, 14 mmol), sodium hydride (456 mg, 19 mmol, 760 mg of a 60% dispersion in mineral oil), iodomethane (1.9 g, 13 mmol) and DMF (approximately 35 mL) was stirred 2 hours. The mixture was poured into ice-water and the mixture was extracted with diethyl ether (2×). The combined extracts were washed with water (3×) and brine (1×) and concentrated to give methyl 6-methoxy-1,3-benzodioxole-5-carboxylate (3 g, 14 mmol), m.p. 74°-75° C.

출처