반응 #168581

반응 방정식

6-chloropurine

(R)-2-[(E)-2-(3-chlorophenyl)vinyl]-pyrrolidine

triethylamine

→

6-[(R)-2-((E)-2-(3-chlorophenyl)vinyl)pyrrolidin-1-yl]-9H-purine

수율 16.5%

용매

1-butanol

반응 조건

후처리

1. 1
   기타For work-up, the batch is partitioned between ethyl acetate and water
2. 2
   건조the organic phase is dried over sodium sulfate
3. 3
   여과filtered off
4. 4
   기타evaporated in vacuo
5. 5
   기타The residue is purified by chromatography

실험 절차

695 mg of 6-chloropurine and 850 mg of (R)-2-[(E)-2-(3-chlorophenyl)vinyl]-pyrrolidine are dissolved in 20 ml of 1-butanol and warmed at 130° C. in the microwave for 6 h with 3.1 ml of triethylamine. For work-up, the batch is partitioned between ethyl acetate and water, the organic phase is dried over sodium sulfate, filtered off and evaporated in vacuo. The residue is purified by chromatography, giving 220 mg of 6-[(R)-2-((E)-2-(3-chlorophenyl)vinyl)pyrrolidin-1-yl]-9H-purine (“A11”); Rt: 1.778 min; [M+H]+326.2; m.p. 194-196°;

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