반응 #1685802

반응 방정식

10-(2-ethoxycarbonylethylamino)-7-chloro-2,3-dihydropyridazino[4,5-b]quinoline-1,4-dione

hydrochloric acid

→

title compound

수율 97.0%

10-(2-Carboxyethylamino)-7-chloro-2,3-dihydropyridazino[4,5-b]quinoline-1,4-dione

수율 97.0%

반응 조건

후처리

1. 1
   온도was refluxed for 1 hr
2. 2
   여과filtered
3. 3
   세척The collected orange solid was washed with water and air
4. 4
   기타dried

실험 절차

A mixture of 10-(2-ethoxycarbonylethylamino)-7-chloro-2,3-dihydropyridazino[4,5-b]quinoline-1,4-dione (0.08 g, 0.22 mM) and 1N hydrochloric acid was refluxed for 1 hr and then cooled to room temperature and filtered. The collected orange solid was washed with water and air dried to provide (0.07 g, 97%) the title compound as an orange powder, mp 356°-359° C.; MS(CI): 335 (M+H).

출처