반응 #1685

반응 방정식

1-isoquinolinecarboxylic acid

hydrogen

→

perhydro-1-isoquinolinecarboxylic acid

수율 56.8%

용매

EtOH

HCl

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through a pad of diatomaceous earth
2. 2
   농축the filtrate was concentrated in vacuo
3. 3
   기타The solid was triturated with water
4. 4
   여과filtered
5. 5
   기타dried

실험 절차

A solution of 1-isoquinolinecarboxylic acid (50 g, 0.288 mol) in EtOH (150 mL) and 60 mL of 5N HCl was reduced over 5% Rh/Al2O3 (14 g) at 52 bar (750 psi) of hydrogen in a high pressure apparatus at 50° C. for 17 hours. The reaction mixture was filtered through a pad of diatomaceous earth, and the filtrate was concentrated in vacuo. The solid was triturated with water, filtered and dried to give DL-perhydro-1-isoquinolinecarboxylic acid (DL-1-Piq-OH) (30 g, 48%) FD-MS 184 (MH+).

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