반응 #1683998

반응 방정식

diethyl ether

1-pentyne

n-butyllithium

2,2-di-tert-butyloxirane

→

3-tert-butyl-2,2-dimethylnon-5-in-3-ol

수율 84.3%

용매

pentane

HMPA

HMPA

반응 조건

후처리

1. 1
   기타The solution obtained
2. 2
   온도was cooled for another 15 minutes
3. 3
   기타the solvent was withdrawn under reduced pressure
4. 4
   기타The raw product obtained

실험 절차

1.26 ml (12.8 mmol) 1-pentyne were added dropwise at 0° C. under argon for 5 minutes to 8.0 ml (12.8 mmol) of a 1.6-molar n-butyllithium solution in pentane. The solution obtained was cooled for another 15 minutes, and then the solvent was withdrawn under reduced pressure. 5 ml HMPA and a solution of 1.0 g (6.4 mmol) 2,2-di-tert-butyloxirane in 2 ml HMPA were added. The reaction solution was stirred for 20 hours at room temperature. Subsequently, it was processed analogous to Example 1. The raw product obtained was cleaned by means of a silica column with 2% diethyl ether/light gasoline. There were obtained 1.21 g (84%) 3-tert-butyl-2,2-dimethylnon-5-in-3-ol

출처