반응 #168338

반응 방정식

Cyclopentene oxide

benzylamine

→

trans-2-(benzylamino)cyclopentanol

용매

EtOAc

반응 조건

후처리

1. 1
   기타microwaved at 150° C. for 3 hours
2. 2
   온도The reaction mixture was then cooled
3. 3
   세척The organic layer was washed with water
4. 4
   건조dried over anhydrous Na2SO4
5. 5
   기타Evaporation of the solvent
6. 6
   기타in vacuo and purification on a silica gel column (0 to 20% MeOH/CH2Cl2)

실험 절차

Cyclopentene oxide (5.0 g, 59.1 mmol), benzylamine (7.0 g, 65.3 mmol) and titanium isopropoxide (3.40 g, 12.0 mmol) were taken in a microwave vial and microwaved at 150° C. for 3 hours. The reaction mixture was then cooled and diluted with EtOAc (100 mL). The organic layer was washed with water and dried over anhydrous Na2SO4. Evaporation of the solvent in vacuo and purification on a silica gel column (0 to 20% MeOH/CH2Cl2) afforded trans-2-(benzylamino)cyclopentanol. MS APCl calc'd for C12H17NO [M+H]+ 192. found 192.

출처