반응 #168129

반응 방정식

NEt3

(S)-1-(4-chloro-phenyl)-ethylamine

3-chloro-1-phenyl-propan-1-one

→

title compound

3-[(S)-1-(4-Chloro-phenyl)-ethylamino]-1-phenyl-propan-1-one

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축Then, the solution was concentrated
2. 2
   workup.ADDITIONwater (100 mL) was added to the residue
3. 3
   추출the resulting mixture was extracted with tert-butyl methyl ether
4. 4
   세척The combined organic extracts were washed with water and brine
5. 5
   건조dried (MgSO4)

실험 절차

NEt3 (60 mL) followed by (S)-1-(4-chloro-phenyl)-ethylamine (20.5 g) was added to a solution of 3-chloro-1-phenyl-propan-1-one (23.2 g) in tetrahydrofuran (200 mL). The resulting mixture was stirred at room temperature overnight. Then, the solution was concentrated, water (100 mL) was added to the residue, and the resulting mixture was extracted with tert-butyl methyl ether. The combined organic extracts were washed with water and brine and dried (MgSO4). The title compound was obtained after removal of the solvent.

출처