반응 #1680997

반응 방정식

Isopropylamine

2-chloro-5-[3-[(methylsulfonyl)oxy]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

→

hydrochloric acid

2-Chloro-5-[3-[(1-methylethyl)amino]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide, hydrochloride salt

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축The mixture was concentrated under reduced pressure
2. 2
   기타the residue purified by solid phase extraction on SCX resin
3. 3
   기타The title produce

실험 절차

Isopropylamine (0.5 ml) was added to a solution of 2-chloro-5-[3-[(methylsulfonyl)oxy]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (0.250 g, Example 6e) in tetrahydrofuran (20 ml) and heated at 70° C. in a sealed tube for 24 h. The mixture was concentrated under reduced pressure and the residue purified by solid phase extraction on SCX resin. The title produce was isolated as the hydrochloric acid salt (0.10 g).

출처