반응 #167935

반응 방정식

racemic (cis)-tert-butyl 4-methoxy-3-methylpiperidine-1-carboxylate

TFA

→

racemic (cis)-4-methoxy-3-methylpiperidine 2,2,2-trifluoroacetate

용매

DCM

반응 조건

후처리

1. 1
   농축The reaction mixture was then concentrated

실험 절차

A solution of racemic (cis)-tert-butyl 4-methoxy-3-methylpiperidine-1-carboxylate (230 mg, 1.0 mmol) in DCM (2 mL) with TFA (0.23 mL, 3.01 mmol) was stirred at room temperature overnight. The reaction mixture was then concentrated to give racemic (cis)-4-methoxy-3-methylpiperidine 2,2,2-trifluoroacetate. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.27 (s, 3 H), 3.01-3.09 (m, 1 H), 2.93-3.00 (m, 1 H), 2.81-2.93 (m, 1 H), 2.69-2.77 (m, 1 H), 1.90-2.08 (m, 2 H), 1.57-1.67 (m, 1 H), 0.90 (d, J=7.1 Hz, 3 H).

출처