반응 #167779

반응 방정식

compound 102

2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

acetonitrile

hydrochloric acid

→

title compound

2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid di hydrochloride

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과The precipitated crystals were collected by filtration

실험 절차

To the compound 102 (1.10 g) in an acetonitrile (44 ml) solution, a 4M hydrochloric acid in ethyl acetate solution (1.5 ml) was added, and the mixture was stirred at room temperature for 5 hours. The precipitated crystals were collected by filtration to obtain the title compound (1.03 g) as a colorless crystal.

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