반응 #167766

반응 방정식

compound 61a

2,2,2-trichloroethyl 2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-5-oxo-2-(phenoxyimino)-1,4-diazepan-4-yl]carbonyl}amino)propyl]-1,3-oxazole-4-carboxylate

→

title compound

수율 23.8%

2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-(phenoxyimino)-1,4-diazepan-1-yl]carbonyl}amino)propyl]-1,3-oxazole-4-carboxylic acid

수율 23.8%

용매

acetic acid

반응 조건

후처리

1. 1
   여과The insolubles were filtered out
2. 2
   농축the filtrate was concentrated
3. 3
   기타the residue was purified by preparative thin layer chromatography (silica gel, chloroform/methanol/acetic acid=8/1/0.25)

실험 절차

To the compound 61a obtained in Step (1) (90 mg) was dissolved in acetic acid (2 ml), zinc powder (180 mg) was added, and the mixture was stirred at room temperature for 3 hours. The insolubles were filtered out, then the filtrate was concentrated, and the residue was purified by preparative thin layer chromatography (silica gel, chloroform/methanol/acetic acid=8/1/0.25) to obtain the title compound (17.4 mg).

출처