반응 #167758

반응 방정식

compound 21

tert-butyl 2-amino-4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazono)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoate

hydrochloric acid

toluene

→

title compound

수율 87.3%

2-amino-4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazono)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

수율 87.3%

용매

acetic acid

반응 조건

후처리

1. 1
   여과the precipitated solid was collected by filtration

실험 절차

To the compound 21 (16 mg), 1 M hydrochloric acid in acetic acid solution was added, and the mixture was stirred at room temperature for 4 hours. To the reaction solution, toluene (5 ml) was added and the precipitated solid was collected by filtration to obtain the title compound (12.7 mg).

출처