반응 #1675547

반응 방정식

dihydropyran

methyl 16-hydroxyhexadecanoate

p-toluenesulfonic acid

NaHCO3

→

methyl 16-(2-tetrahydropyranyloxy)hexadecanoate

용매

dichloromethane

반응 조건

후처리

1. 1
   기타equipped with a stirrer and a dropping funnel
2. 2
   workup.ADDITIONAfter the completion of the addition
3. 3
   workup.STIRRINGthe mixture was stirred at room temperature for an hour
4. 4
   기타the reaction
5. 5
   여과After filtering
6. 6
   기타removing solvent under reduced pressure

실험 절차

100.26 g (0.35 mol) of methyl 16-hydroxyhexadecanoate, 0.60 g (3.5 mmol) of p-toluenesulfonic acid and 350 ml of dichloromethane were introduced into a 1-l flask equipped with a stirrer and a dropping funnel. 32.39 g (0.385 mol) of dihydropyran was added dropwise thereto while stirring at 0° C. After the completion of the addition, the mixture was stirred at room temperature for an hour to thereby complete the reaction. Next, the reaction mixture was neutralized by adding 0.59 g (7 mmol) of NaHCO3. After filtering and removing solvent under reduced pressure; a crude product of methyl 16-(2-tetrahydropyranyloxy)hexadecanoate was obtained.

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