반응 #167453

반응 방정식

4-Methyl-pyridin-3-ylamine

1-chloro-2-isocyanato-2-methyl-propane

MeOH

→

product

수율 97.1%

1-(2-Chloro-1,1-dimethyl-ethyl)-3-(4-methyl-pyridin-3-yl)-urea

수율 97.1%

용매

toluene

CHCl3

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   기타the residue was dried

실험 절차

4-Methyl-pyridin-3-ylamine (1.98 g, 18.33 mmol) was added to solution of 1-chloro-2-isocyanato-2-methyl-propane (I-200c: 3 g, 20.40 mmol) in toluene (30 mL). The resulting mixture was stirred at room temperature for 3 days. The reaction was monitored by TLC (5% MeOH in CHCl3). The reaction mixture was filtered and the residue was dried to afford 4.3 g of the product (87.75% yield).

출처