반응 #167384

반응 방정식

1-benzothiazol-6-yl-imidazolidin-2-one

2-(3-bromo-pyridin-4-yl)-propan-2-ol

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

수율 19.0%

1-(benzo[d]thiazol-6-yl)-3-(4-(2-hydroxypropan-2-yl)pyridin-3-yl)imidazolidin-2-one

수율 19.0%

용매

1,4-dioxane

반응 조건

후처리

1. 1
   기타the same reaction conditions
2. 2
   기타to afford the crude product
3. 3
   기타Purification by preparative HPLC

실험 절차

Using the same reaction conditions as described in example 14, 1-benzothiazol-6-yl-imidazolidin-2-one (I-84b: 125 mg, 0.57 mmol) was reacted with 2-(3-bromo-pyridin-4-yl)-propan-2-ol (SM-156a: 122.7 mg, 0.57 mmol), 1,4-dioxane (5 mL), copper iodide (10.85 mg, 0.057 mmol), trans-1,2-diamino cyclohexane (19.57 mg, 0.171 mmol) and potassium phosphate (362.9 mg, 1.71 mmol) to afford the crude product. Purification by preparative HPLC afforded 38 mg of the product (19% yield).

출처