반응 #167369

반응 방정식

Bromine

1H-indole-4-carbonitrile

sodium metabisulphite

ethylacetate

→

3-Bromo-1H-indole-4-carbonitrile

수율 78.4%

용매

hexane

DMF

DMF

반응 조건

후처리

1. 1
   기타The precipitate was collected
2. 2
   세척washed with cold water
3. 3
   기타dried

실험 절차

Bromine in DMF (0.796 g, 4.975 mmol) was added to a stirred solution of 1H-indole-4-carbonitrile (700 mg, 4.9295 mmol) in DMF (15 mL) at room temperature. The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (10% ethylacetate in hexane). The reaction mixture was poured into ice water containing 0.5% ammonia and 0.5% sodium metabisulphite. The precipitate was collected, washed with cold water and dried to afford 850 mg of 3-Bromo-1H-indole-4-carbonitrile (78.41% yield).

출처