반응 #167346

반응 방정식

1-Chloro-3-isocyanato-propane

4-methyl-pyridin-3-ylamine

ethylacetate

→

1-(3-chloro-propyl)-3-(4-methyl-pyridin-3-yl)-urea

수율 100.7%

용매

toluene

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   세척washed with toluene
3. 3
   기타dried under reduced pressure

실험 절차

1-Chloro-3-isocyanato-propane (1.6 g, 13.87 mmol) was added dropwise to a stirred solution of 4-methyl-pyridin-3-ylamine (1 g, 9.25 mmol) in toluene (15 mL) at 0° C. The reaction mixture was stirred at room temperature for 18 hours. The reaction was monitored by TLC (100% ethylacetate). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 2.12 g (99.5% yield) of 1-(3-chloro-propyl)-3-(4-methyl-pyridin-3-yl)-urea.

출처