반응 #167325

반응 방정식

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

2-chloro-4-iodo-benzonitrile

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

수율 32.1%

2-Chloro-4-[3-(4-methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzonitrile

수율 32.1%

용매

1,4-dioxane

반응 조건

후처리

1. 1
   기타to afford the crude product which
2. 2
   기타was purified by column chromatography on silica gel (2% MeOH in CHCl3)
3. 3
   세척The residue was washed with hexane
4. 4
   기타dried

실험 절차

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.8465 mmol) was reacted with 2-chloro-4-iodo-benzonitrile (245.3 mg. 0.9311 mmol), 1,4-dioxane (20 mL), copper iodide (16.1 mg, 0.08465 mmol), trans-1,2-diamino cyclohexane (12.6 mg, 0.1100 mmol) and potassium phosphate (30.6 mL, 0.254 mmol) to afford the crude product which was purified by column chromatography on silica gel (2% MeOH in CHCl3). The residue was washed with hexane and dried to afford 85 mg of the product (32% yield).

출처