반응 #167291

반응 방정식

1-Chloro-2-isocyanato-ethane

benzothiazol-6-ylamine

ethyl acetate

→

1-benzothiazol-6-yl-3-(2-chloro-ethyl)-urea

수율 80.2%

용매

toluene

hexane

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   세척washed with toluene
3. 3
   기타dried under reduced pressure

실험 절차

1-Chloro-2-isocyanato-ethane (2.1 g, 19.99 mmol) was added drop wise to a stirred solution of benzothiazol-6-ylamine (2 g, 13.33 mmol) in toluene (80 mL) over a period of 15 minutes at 0° C. The reaction mixture was stirred at room temperature for 18 hours. The reaction was monitored by TLC (50% ethyl acetate in hexane). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 2.73 g (80.2% yield) of 1-benzothiazol-6-yl-3-(2-chloro-ethyl)-urea.

출처